Genetic Modification to Protect Pig Islets From T Cell-Mediated Xenogeneic Rejection

Characterisation of transgenic pigs expressing a human T cell-depleting anti-CD2 monoclonal antibody

Evelyn J Salvaris, Nella Fisicaro, Stephen Mcilfatrick, Adwin Thomas, Erin Fuller, Andrew M Lew, Mark B Nottle, Wayne J Hawthorne, Peter J Cowan

2024-01-01

Background: Pig islet xenotransplantation is a potential treatment for type 1 diabetes. We have shown that maintenance immunosuppr..

Xenotransplantation of Genetically Modified Neonatal Pig Islets Cures Diabetes in Baboons

WJ Hawthorne, EJ Salvaris, YV Chew, H Burns, J Hawkes, H Barlow, M Hu, AM Lew, MB Nottle, PJ O’Connell, PJ Cowan

2022-06-16

Xenotransplantation using porcine donors is rapidly approaching clinical applicability as an alternative therapy for treatment of ..

FokI-dCas9 mediates high-fidelity genome editing in pigs

N Fisicaro, EJ Salvaris, GK Philip, MJ Wakefield, MB Nottle, WJ Hawthorne, PJ Cowan

2020-01-01

Gene editing using clustered regularly interspaced short palindromic repeats/Cas9 has great potential for improving the compatibil..

Targeted insertion of an anti-CD2 monoclonal antibody transgene into the GGTA1 locus in pigs using FokI-dCas9

MB Nottle, EJ Salvaris, N Fisicaro, S McIlfatrick, I Vassiliev, WJ Hawthorne, PJ O'Connell, JL Brady, AM Lew, PJ Cowan

2017-12-01

Xenotransplantation from pigs has been advocated as a solution to the perennial shortage of donated human organs and tissues. CRIS..